ABSTRACT
Sarcoidosis is an idiopathic granulomatous disease and can virtually affect any organ system. Multiple factors, including tubercular antigens organic and environmental exposures, have been implicated in its pathogenesis. In addition to drugs, sarcoid-like reactions have been reported following varicella and influenza vaccination. Few reports of erythema nodosum and Lofgren syndrome have been reported after the COVID19 vaccination, though no histologic diagnosis was pursued in these cases. We herein report a case of sarcoidosis presenting with bilateral acute onset vision loss with a temporal association with COVID19 vaccination (ChadOx-1 n-COV, COVISHIELDTM). Symptoms started within two weeks of receiving the vaccine. Alternate causes for optic neuritis were excluded. Transbronchial lung biopsy showed the presence of non-caseating epithelioid cell granulomas. The patient received high-dose corticosteroids immediately after diagnosis, albeit with incomplete clinical improvement in vision on a three-month follow-up. In conclusion, we report a novel case of sarcoidosis-related optic neuritis following COVID19 vaccination.
ABSTRACT
Background: The world is struggling with the rising number of covid-19 cases. Few studies are available to propose the effect of menopause on covid-19. We are submitting a research article targeted at identifying menopause as an independent risk factor for severe Covid-19. Aims and Objectives: Determine whether menopausal women are at higher risk of developing severe Covid-19 infection as compared to menstruating women of the same age group. Materials and Methods: A retrospective cross-sectional study that included patients ages varies from 40 to 55 years from the medical record department of LNMC Bhopal, India. We enrolled 65 female patients after analysing records of 2500 patients. We divided the entire study population into two groups, the menopause group, and the non-menopausal group. Result: Out of 65 patients, 27 patients were in the menopause group, and 38 patients were in the non-menopause group. The mean D-dimer in the menopause group is 1100.78 ng/ml and in the non-menopause group is 727.63 ng/ml, which is statistically significant. (p-value 0.04) The mean value of C-Reactive protein is 27.11 mg/l and 16.74 mg/l among the menopause and non-menopause groups, respectively (p-value0.041). Twelve out of 17 patients who develop moderate-to-severe disease belong to the menopause group and five patients in the non-menopause group (p-value 0.005). Conclusion: In the present study, we witnessed that the disease is more severe in the menopause group than in the non-menopause group (p<0.005). This study can help recognize the high-risk cases and may be helpful to plan the treatment policies for the menopausal women who contract the Covid-19. [ABSTRACT FROM AUTHOR] Copyright of Asian Journal of Medical Sciences is the property of Manipal Colleges of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)